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The 244-cc lay-down-sally single powering the Helix offered water cooling and a scintillating 19 horsepower. A V-matic CVT means pretty much anybody can ride one, while a 75 MPH top speed ensures that all those folks will mostly be able to get out of people’s way. A drum rear brake and disc up front—a first for a Honda scooter here in the U.S.—provide stopping duties. These bikes even offered an electric start and automatic choke so getting one lit up means only depressing the brake pedal and thumbing the starter switch.

This ’99, in Pure Red, comes with just 171 miles under its belt. The seller says that other than a couple of scratches in the paint and a nick here or there, the bike is as you might have expected it in the dealer showroom. Hey, remember when there used to be motorcycle dealer showrooms here?

The two-up saddle looks as comfy as Santa’s lap and while there is a hump dividing the floorboards meaning that it’s not a true step-thru, it’s still easier to mount and manage the bike’s 349 pounds than would be a traditional swing-your-leg-over motorcycle.

Full digital instrumentation greets you when you do take your seat, just like in Hnda’s S2000 automobile. You even get a gas gauge for the 3.2-gallon tank. That tank, by the way, should allow about 180 miles between fuel stops.

The question right now is whether this Helix’s $2,499 price tag should be a full stop. The Helix has an odd history of missed model years owing to a glut of product on the sales floor, while alternatively having to be reintroduced in other markets due to consumers having clamored for its return.

Today you still see them on the road if you’re paying attention—which you should be. What we want to know is, at that $2,499 price, should this low mileage example be seen back on the road?

You decide!

Nice Price or Crack Pipe: 1999 Honda CN250 Helix for $2,499.
Vote Polldaddy.com

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W hile NextGen SVN is well under way, the community development team has been busy working on the next release — “1.10” aimed at a March timeframe. While the GA release is still many weeks away, the software has entered a critical phase — late-stage testing — which means that it’s ready for external testing with a larger user base!

I recently caught up with our very own Julian Foad who is the community release manager for 1.10 and he’s shared some updated insights on the upcoming effort.

In short, three major areas have been the focus, all of which give strong benefits to enterprise software teams:

Faster commits — Large file performance  — Subversion has long been a go to version control technology for versioning large binary files. As I wrote in a previous article , teams working with digital content such as Game studios typically see a dizzying amount of large files in their projects. A key objective for managing large files must always be performance. Any improvement to this feature has immediate impact for users.

The point of a version control system is to support team based software development workflows and removing the concept of a working copy is synonymous to “doing all operations remotely” — there is no local file on your computer, all operations happen on the server. This model does not make any sense in a collaboration environment because enterprise repos are big, all commits usually have more than one file and commits in certain cases could be GB+ in size.

But… what if there was a way to improve the performance but retain this secure and reliable workflow? That’s exactly what one developer did with his patch to introduce compression to the backend. Zlib (DEFLATE) is an old algorithm — LZ4 allows extremely fast performance using the latest CPU advances.

With LZ4, users can expect up to 300% increases in commit performance when 1.10 rolls out! That’s a big deal for enterprise software development teams.

The community development team is very happy to see that 1.10 will bring faster performance for large binary files. This is another great add for the Subversion user base in the enterprise — building complex projects that span source code and large binary assets alike.

Faster HTTP(S)  — Next on the list for performance is a little upgrade to the popular HTTP(S) transport. The svn client will be able compress data over http(s) endpoints when possible when interacting with a recent Mod_Dav module version. A developer submitted a patch to include this negotiation capability — win.

Overall this is a great addition to the Subversion user base already in the Cloud. HTTP(S) now gets closer to SVN+SSH performance while retaining the infrastructure simplicity inherent in HTTP(S) (notably on the security side).

Will your favorite Subversion desktop app take advantage? Yes, the desktop apps that use the Subversion native API will immediately be able to negotiate “faster” HTTP performance with the server side with no changes. Check out TortoiseSVN on NextGen SVN to realize Shelving on Windows today.

Better Merging User Experience —  Merging in Subversion has been a long standing pain. Ask any enterprise software team about what is most painful with Subversion and you’ll get the answer “merging” 9/10 times. Why is it so painful? Well for one, complex/modern merging was never a first class citizen case for Subversion. Further, it has not been significantly touched since version 1.5 (other than the reintegrate changes in 1.8). Alas, Subversion users can rejoice as 1.10 take a big chunk of this problem away with a revised conflict resolution module to better automate the process of merging. While a single step, it is an important one — expect more improvements to merging in the future.

This feature takes a very large step towards moving the pain of merging away from the user. Only under dire-straights should Subversion have the user take action — what is a computer’s value if its cannot automate things for you?!

—  Julian Foad

Shelving gets mainlined from NextGen SVN Branch —  While developing one change, you need to stop and work on an urgent fix or you want to commit a quick and easy change or try a different approach in the same code. You need to store the unfinished work and return to it later. Tis is table-stakes in terms of modern developer needs.

The solution in 1.10 is one-click patch management on top of ‘svn diff’ and ‘svn patch’.

— Julian Foad

Stay tuned for more updates by following me or get on Twitter to keep up to date on 1.10 and 1.11 developments.

Happy SVN-ing!

Like what you read? Give Jacek Materna a round of applause.

From a quick cheer to a standing ovation, clap to show how much you enjoyed this story.

Inactivation of one X chromosome in female mammals ensures gene dosage compensation between males and females. The establishment and maintenance of this silent state has often been used as a classic example of facultative heterochromatin formation (reviewed by Plath et al., 2002 ; Heard, 2004 ). Certainly, the process has many features that might be common to other examples of gene silencing. Random X inactivation occurs in the early embryo, initially in cells derived from the inner cell mass of the blastocyst. Conveniently, aspects of the process can be easily studied in ES cells as they undergo differentiation.

One of the earliest recognized events is expression of the noncoding RNA Xist initially from both X chromosomes. Ultimately, transcription is stabilized only from the prospective inactive X and the Xist RNA coats the silenced chromosome. Establishment of Xist expression is regulated by the transcription of an antisense RNA, Tsix ( Lee et al., 1999 ), which blocks Xist transcription on the future active X chromosome. Xist expression may also be affected by other noncoding RNAs, such as the newly discovered Xite ( Ogawa and Lee, 2003 ). However, recent evidence suggests that certain chromatin modifications may precede stable monoallelic Xist transcription, at least in female ES cells. O'Neill and coworkers have described core histone hyperacetylation, H3 Lys4 dimethylation and H3 Lys9 hypomethylation on both of the active X chromosomes prior to the onset of inactivation in undifferentiated female ES cells ( O'Neill et al., 2003 ). This cocktail of modifications is distinct from the marks on the X chromosome in male cells or those at autosomal loci, and might signal the presence of more than one X chromosome.

The transient recruitment of the Eed/Ezh2 polycomb complex, and associated H3 Lys27 methylation, to the future inactive X chromosome is another early event in the inactivation process ( Plath et al., 2003 ; Dion Lee buttoned jacket Clearance Brand New Unisex Sale Top Quality Countdown Package Online Cheap Price Low Price Fee Shipping For Sale gwweM3Lg
). Subsequently, further heterochromatic proteins and chromatin-modifying enzymes are recruited. The fully inactivated X chromosome is characterized by hypoacetylated histones H2A, H2B, H3 and H4 ( Boggs et al., 1996 ; Jeppesen and Turner, 1993 ), dimethylated H3 Lys9 and trimethylated H3 Lys27 with hypomethylation at H3 Lys4 ( Chadwick and Willard, 2003 ), enrichment of the histone variant macroH2A1 ( Costanzi and Pehrson, 1998 ) and DNA methylation at the promoters of silenced genes ( Fenty X Puma zip front racing jacket Outlet Top Quality Discount Great Deals Cheap Sale Classic Cheap Sale Get To Buy Authentic nYWFJU6TIV
), and it replicates late in S phase ( Morishima et al., 1962 ). Intriguingly, promoter-specific dimethylation of H3 Lys4 is also found at autosomal imprinted loci as well as genes subject to X inactivation, which suggests that it might be a conserved epigenetic mark for monoallelic expression ( Rougeulle et al., 2003 ). Despite the majority of the X chromosome entering a silent state, several genes in the murine distal pseudoautosomal region as well as Xist escape inactivation. In humans, an increasing number of genes are believed to be expressed from both X chromosomes ( Carrel et al., 1999 ), although the mechanism by which this is achieved is unknown.

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